Preston Lab at RCSI

Publications

Type 1 VWD classification revisited: novel insights from combined analysis of the LoVIC and WiN studies

 Ferdows Atiq, Robin Blok, Calvin B van Kwawegen, Dearbhla Doherty, Michelle Lavin, Johanna G van der Bom, Niamh M O'Connell, Joke de Meris, Kevin Ryan, Saskia E M Schols, Mary Byrne, Floor C J I Heubel-Moenen, Karin P M van Galen, Roger J S Preston, Marjon H Cnossen, Karin Fijnvandraat, Ross I Baker, Karina Meijer, Paula James, Jorge Di Paola, Jeroen Eikenboom, Frank W G Leebeek, James S O'Donnell, pmid:38142407, pmc:PMC11033584, doi:10.1182/blood.2023022457,

Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability

 Aisling M Rehill, Gemma Leon, Sean McCluskey, Ingmar Schoen, Yasmina Hernandez-Santana, Stephanie Annett, Paula Klavina, Tracy Robson, Annie M Curtis, Thomas Renné, Seamus Hussey, James S O'Donnell, Patrick T Walsh, Roger J S Preston, pmid:37865288, doi:10.1016/j.jtha.2023.10.006,

VWF-ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion

 Helen Fogarty, Azaz Ahmad, Ferdows Atiq, Dearbhla Doherty, Soracha Ward, Ellie Karampini, Aisling Rehill, Gemma Leon, Ciara Byrne, Rosena Geoghegan, Helena Conroy, Mary Byrne, Ulrich Budde, Sonja Schneppenheim, Ciara Sheehan, Noel Ngwenya, Ross I Baker, Roger J S Preston, Emma Tuohy, Corrina McMahon, James S O'Donnell, pmid:37773926, pmc:PMC10690561, doi:10.1182/bloodadvances.2023010824,

Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

 Tristram A J Ryan, Alexander Hooftman, Aisling M Rehill, Matt D Johansen, Eóin C O' Brien, Juliana E Toller-Kawahisa, Mieszko M Wilk, Emily A Day, Hauke J Weiss, Pourya Sarvari, Emilio G Vozza, Fabian Schramm, Christian G Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G Hansbro, Gavin McManus, Laura O'Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G Fallon, Kingston H G Mills, Emma M Creagh, James S O' Donnell, Paul J Hertzog, Philip M Hansbro, Rachel M McLoughlin, Małgorzata Wygrecka, Roger J S Preston, Zbigniew Zasłona, Luke A J O'Neill, pmid:37474527, pmc:PMC10359340, doi:10.1038/s41467-023-40034-1,

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

 Tristram A J Ryan, Alexander Hooftman, Aisling M Rehill, Matt D Johansen, Eóin C O' Brien, Juliana E Toller-Kawahisa, Mieszko M Wilk, Emily A Day, Hauke J Weiss, Pourya Sarvari, Emilio G Vozza, Fabian Schramm, Christian G Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G Hansbro, Gavin McManus, Laura O'Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Clíona Ní Cheallaigh, Niall Conlon, Michael Carty, Padraic G Fallon, Kingston H G Mills, Emma M Creagh, James S O' Donnell, Paul J Hertzog, Philip M Hansbro, Rachel M McLoughlin, Małgorzata Wygrecka, Roger J S Preston, Zbigniew Zasłona, Luke A J O'Neill, pmid:37316487, pmc:PMC10265568, doi:10.1038/s41467-023-39174-1,

Targeting NETs using dual-active DNase1 variants

 Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K Mailer, Manu Beerens, Julian C Gerwers, Roger J S Preston, Jacob Odeberg, Lynn M Butler, Coen Maas, Evi X Stavrou, Tobias A Fuchs, Thomas Renné, pmid:37287977, pmc:PMC10242134, doi:10.3389/fimmu.2023.1181761,

Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor

 Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G Fallon, Roger J S Preston, John Gormley, Kevin Ryan, Niamh M O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P Crowley, Susan I O'Shea, Birgit M Reipert, Jill M Johnsen, Steven W Pipe, Jorge Di Paola, Peter L Turecek, James S O'Donnell, iPATH study group, pmid:36775768, doi:10.1016/j.jtha.2023.01.013,

The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing

 Mariana P Cervantes-Silva, Richard G Carroll, Mieszko M Wilk, Diana Moreira, Cloe A Payet, James R O'Siorain, Shannon L Cox, Lauren E Fagan, Paula A Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M Buel, George A Timmons, James O Early, Roger J S Preston, Jennifer M Hurley, David K Finlay, Ingmar Schoen, F Javier Sánchez-García, Kingston H G Mills, Annie M Curtis, pmid:36470865, pmc:PMC9722918, doi:10.1038/s41467-022-34897-z,

von Willebrand factor links primary hemostasis to innate immunity

 Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P Cervantes, Annie M Curtis, Heike C Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J S Preston, Jamie M O'Sullivan, Frederick J Sheedy, Padraic Fallon, James S O'Donnell, pmid:36329021, pmc:PMC9633696, doi:10.1038/s41467-022-33796-7,

Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

 Helen Fogarty, Soracha E Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W Mallon, Gerard F Curley, Roger J S Preston, Aisling M Rehill, Ross I Baker, Cliona Ni Cheallaigh, James S O'Donnell, Irish COVID-19 Vasculopathy Study (iCVS) Investigators, pmid:35875995, pmc:PMC9349977, doi:10.1111/jth.15830,

The protein C pathways

 Gemma Leon, Aisling M Rehill, Roger J S Preston, pmid:35852855, doi:10.1097/MOH.0000000000000726,

Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress

 Robert A Ariëns, Beverley J Hunt, Ejaife O Agbani, Josefin Ahnström, Robert Ahrends, Raza Alikhan, Alice Assinger, Zsuzsa Bagoly, Alessandra Balduini, Elena Barbon, Christopher D Barrett, Paul Batty, Jorge David Aivazoglou Carneiro, Wee Shian Chan, Moniek de Maat, Kerstin de Wit, Cécile Denis, Martin H Ellis, Renee Eslick, Hongxia Fu, Catherine P M Hayward, Benoit Ho-Tin-Noé, Frederikus A Klok, Riten Kumar, Karin Leiderman, Rustem I Litvinov, Nigel Mackman, Zoe McQuilten, Matthew D Neal, William A E Parker, Roger J S Preston, Julie Rayes, Alireza R Rezaie, Lara N Roberts, Bianca Rocca, Susan Shapiro, Deborah M Siegal, Lirlândia P Sousa, Katsue Suzuki-Inoue, Tahira Zafar, Jiaxi Zhou, pmid:35814801, pmc:PMC9257378, doi:10.1002/rth2.12747,

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

 Marco Heestermans, Clément Naudin, Reiner K Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A Friese, Mathias Gelderblom, Albert Sickmann, Roger J S Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M Butler, Ophira Salomon, Evi X Stavrou, Thomas Renné, pmid:34552086, pmc:PMC8458485, doi:10.1038/s41467-021-25888-7,

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

 Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, Claire Comerford, Ellie Karampini, Hanna Englert, Mary Byrne, Colm Bergin, Jamie M O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W Mallon, Gerard F Curley, Roger J S Preston, Aisling M Rehill, Dennis McGonagle, Cliona Ni Cheallaigh, Ross I Baker, Thomas Renné, Soracha E Ward, James S O'Donnell, Irish COVID-19 Vasculopathy Study (iCVS) investigators, pmid:34375505, pmc:PMC8420256, doi:10.1111/jth.15490,

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

 Mark M Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C Runtsch, Anne F McGettrick, Caroline E Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G Casarotto, Jane E Dahlstrom, Eva M Palsson-McDermott, Sinead C Corr, Kingston H G Mills, Roger J S Preston, Nouri Neamati, Yiyue Xie, Jonathan B Baell, Philip G Board, Luke A J O'Neill, pmid:31577945, doi:10.1016/j.celrep.2019.08.072,

Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels

 Michelle Lavin, Sonia Aguila, Sonja Schneppenheim, Niall Dalton, Kenneth L Jones, Jamie M O'Sullivan, Niamh M O'Connell, Kevin Ryan, Barry White, Mary Byrne, Marie Rafferty, Mairead M Doyle, Margaret Nolan, Roger J S Preston, Ulrich Budde, Paula James, Jorge Di Paola, James S O'Donnell, pmid:28916584, pmc:PMC5881608, doi:10.1182/blood-2017-05-786699,