We are delighted to have published a new research article in Science Advances. This was performed in collaboration with other groups in the RCSI Irish Centre for Vascular Biology and Trinity College Dublin.
Postdoctoral researcher Dr Aisling Rehill was the lead-author on the work, which showed for the first time that trained immunity, a type of immune memory associated with the innate immune system, causes myeloid cell hypercoagulability.
In this study, we demonstrated that prior exposure of myeloid cells to trained immunity mediators triggers epigenetic and metabolic reprogramming. This process accelerates tissue factor expression and decryption while enhancing antifibrinolytic activity. Additionally, we show that inducing trained immunity in mice leads to the reprogramming of bone marrow progenitor cells, driving sustained myeloid cell and plasma procoagulant activity for weeks after the initial exposure.
These findings reveal that a lowered threshold for myeloid cell-driven hypercoagulability is a maladaptive consequence of trained immunity.
Congratulations, Aisling and to everyone else involved!
