Preston Lab

Irish Centre for Vascular Biology

The Preston Lab is located at the Royal College of Surgeons in Ireland (RCSI) and is part of the Irish Centre for Vascular Biology and the School of Pharmacy and Biomolecular Sciences.

We are interested in how coagulation proteases in the blood communicate with cells. We are particularly interested in the protein C pathway, whose multiple biological roles provide opportunities to engineer new therapeutic agents for haematological and inflammatory disease. In addition, we study how inflammation affects immune cell-mediated hypercoagulability in different disease cohorts.

Our group aims to develop new therapeutic and diagnostic approaches for treatment of haematological and inflammatory disorders.

Funding Support

Science Foundation Ireland

SFI Frontiers for the Future Award

National Children's Research Centre

Project Grant Award

Health Research Board

Investigator-Led Project Award

Irish Research Council

Postgraduate Studentship

Publications

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Enhanced α2-3 linked sialylation determines the extended half-life of CHO-rVWF

Ciara Byrne, Soracha Ward, Jamie M O'Sullivan, Alain Chan Kwo Chion, Patricia Lopes, Bogdan Baci, Caoimhe Dowd, Darragh Jordan, Ross Ian Baker, Roger Preston, Marco Monopoli, Peter L Turecek, Maximilianos Kotsias, Jack Cheeseman, Alan Moran, Richard A Gardner, Daniel I R Spencer, Ferdows Atiq, James S O'Donnell, pmid:40101144, doi:10.1182/blood.2024027038,

Trained immunity causes myeloid cell hypercoagulability

Aisling M Rehill, Seán McCluskey, Anna E Ledwith, Tristram A J Ryan, Betül Ünlü, Gemma Leon, Hugo Charles-Messance, Edmund H Gilbert, Paula Klavina, Emily A Day, Judith Coppinger, Jamie M O'Sullivan, Corrina McMahon, James S O'Donnell, Annie M Curtis, Luke A J O'Neill, Frederick J Sheedy, Roger J S Preston, pmid:40053582, pmc:PMC11887800, doi:10.1126/sciadv.ads0105,

Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4

Hanna Englert, Chandini Rangaswamy, Giuliano A Kullik, Mylène Divivier, Josephine Göbel, Irm Hermans-Borgmeyer, Uwe Borgmeyer, Kerri A Mowen, Manu Beerens, Maike Frye, Reiner K Mailer, Mathias Gelderblom, Evi X Stavrou, Roger J S Preston, Stefan W Schneider, Tobias A Fuchs, Thomas Renné, pmid:39777764, pmc:PMC11707982, doi:10.1096/fj.202402514R,