Preston Lab

Irish Centre for Vascular Biology

The Preston Lab is located at the Royal College of Surgeons in Ireland (RCSI) and is part of the Irish Centre for Vascular Biology and the School of Pharmacy and Biomolecular Sciences.

We are interested in how coagulation proteases in the blood communicate with cells. We are particularly interested in the protein C pathway, whose multiple biological roles provide opportunities to engineer new therapeutic agents for haematological and inflammatory disease. In addition, we study how inflammation affects immune cell-mediated hypercoagulability in different disease cohorts.

News

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Eberhard F. Mammen Young Investigator Award 2022

Well done to Dr Aisling Rehill who was recently awarded the prestigious Eberhard F. Mammen Young Investigator Award 2022.

This award was based on her oral communication presented at the International Society of Thrombosis and Haemostasis (ISTH) annual conference.

https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-57033.pdf

Date: 01.07.23

Awards at ISI 2022

Congratulations to Gemma and Aisling, who both won awards at the Irish Society for Immunology 2022 annual meeting in Maynooth this year. Gemma won 'Best Postdoc Oral Presentation Award' and Aisling won 'Best Poster' Prize.

Awards at HAI 2022

The lab attended the Haematology Association of Ireland 2022 annual meeting in Cork. Congratulations to Aisling, who presented her recent findings and was awarded 'Best Scientific Oral Presentation.

Our group aims to develop new therapeutic and diagnostic approaches for treatment of haematological and inflammatory disorders.

Funding Support

Science Foundation Ireland

SFI Frontiers for the Future Award

National Children's Research Centre

Project Grant Award

Health Research Board

Investigator-Led Project Award

Irish Research Council

Postgraduate Studentship

Publications

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Mimicking activated protein C-progress by PARtnering peptides

Harry Fleming, Roger J S Preston, pmid:39048268, doi:10.1016/j.jtha.2024.05.003,

Aptamer BT200 blocks interaction of K1405-1408 in the VWF-A1 domain with macrophage LRP1

Alain Chan Kwo Chion, Ciara Byrne, Ferdows Atiq, Dearbhla Doherty, Sonia Aguila, Judicael Fazavana, Patricia Lopes, Ellie Karampini, Aamir Amin, Roger J S Preston, Ross Ian Baker, Thomas Aj McKinnon, Shuhao Zhu, James C Gilbert, Jonas Emsley, Bernd Jilma, James S O'Donnell, pmid:38996211, doi:10.1182/blood.2024024055,

Peptidylarginine deiminase 4: casting the NET over obesity?

Gemma Leon, Roger J S Preston, pmid:38670685, doi:10.1016/j.jtha.2024.02.004,

The Role of Myeloid Cells in Thromboinflammatory Disease

David Noone, Roger J S Preston, Aisling M Rehill, pmid:38547918, doi:10.1055/s-0044-1782660,

Type 1 VWD classification revisited: novel insights from combined analysis of the LoVIC and WiN studies

Ferdows Atiq, Robin Blok, Calvin B van Kwawegen, Dearbhla Doherty, Michelle Lavin, Johanna G van der Bom, Niamh M O'Connell, Joke de Meris, Kevin Ryan, Saskia E M Schols, Mary Byrne, Floor C J I Heubel-Moenen, Karin P M van Galen, Roger J S Preston, Marjon H Cnossen, Karin Fijnvandraat, Ross I Baker, Karina Meijer, Paula James, Jorge Di Paola, Jeroen Eikenboom, Frank W G Leebeek, James S O'Donnell, pmid:38142407, pmc:PMC11033584, doi:10.1182/blood.2023022457,

Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability

Aisling M Rehill, Gemma Leon, Sean McCluskey, Ingmar Schoen, Yasmina Hernandez-Santana, Stephanie Annett, Paula Klavina, Tracy Robson, Annie M Curtis, Thomas Renné, Seamus Hussey, James S O'Donnell, Patrick T Walsh, Roger J S Preston, pmid:37865288, doi:10.1016/j.jtha.2023.10.006,